Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4
Abstract Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The…
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The potential of cannabidiol in the COVID-19 pandemic
Identifying candidate drugs effective in the new coronavirus disease 2019 (Covid‐19) is crucial, pending a vaccine against SARS‐CoV2….
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Fighting the storm: novel anti- TNFα and anti-IL-6 C. sativa lines to tame cytokine storm in COVID-19
Overall, we are the first to show that application of C. sativa extracts profoundly decreases the level of…
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Acute inflammation and pathogenesis of SARS-CoV-2 infection: Cannabidiol as a potential anti-inflammatory treatment?
In murine models of lung injury, CBD reduced lipopolysaccharide (LPS)-induced acute pulmonary inflammation [41,42]. In rat models of…
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SARS-CoV2 induced respiratory distress: Can cannabinoids be added to anti-viral therapies to reduce lung inflammation?
Like Δ9-tetrahydrocannabinol (Δ9-THC), the most well-studied cannabinoid, CBD decreased lung inflammation in a murine model of acute lung…
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In Search of Preventative Strategies: Novel Anti-Inflammatory High-CBD Cannabis Sativa Extracts Modulate ACE2 Expression in COVID-19 Gateway Tissues
The observed down-regulation of ACE2 gene expression by several tested extracts of C. sativa is a novel and…
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Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures
Abstract Radiotherapy combined with chemotherapy is the major treatment modality for human glioblastoma multiforme (GBM). GBMs eventually relapse…
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Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
Abstract According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in…
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ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Abstract Glioblastoma is the most common primary brain tumor in adults. While the introduction of temozolomide chemotherapy has…
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Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells
Abstract The main chemical component of cannabis, cannabidiol (CBD), has been shown to have antitumor properties. The present…