Cannabidiol on the Path from the Lab to the Cancer Patient: Opportunities and Challenges
Abstract Cannabidiol (CBD), a major non-psychotropic component of cannabis, is receiving growing attention as a potential anticancer agent….
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Inhalant Cannabidiol Inhibits Glioblastoma Progression Through Regulation of Tumor Microenvironment
Abstract Introduction: Glioblastoma (GBM) is the most common invasive brain tumor composed of diverse cell types with poor prognosis….
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Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4
Abstract Glioma is the most common primary malignant brain tumor with poor survival and limited therapeutic options. The…
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Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures
Abstract Radiotherapy combined with chemotherapy is the major treatment modality for human glioblastoma multiforme (GBM). GBMs eventually relapse…
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ID1 Is Critical for Tumorigenesis and Regulates Chemoresistance in Glioblastoma
Abstract Glioblastoma is the most common primary brain tumor in adults. While the introduction of temozolomide chemotherapy has…
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Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells
Abstract Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumor in adults,…
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Inhibition of ATM kinase upregulates levels of cell death induced by cannabidiol and γ-irradiation in human glioblastoma cells
Abstract Despite advances in glioblastoma (GBM) therapy, prognosis of the disease remains poor with a low survival rate….
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Regulation of human glioblastoma cell death by combined treatment of cannabidiol, γ-radiation and small molecule inhibitors of cell signaling pathways
Abstract Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. The challenging problem in cancer…
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Quantitative Analyses of Synergistic Responses between Cannabidiol and DNA-Damaging Agents on the Proliferation and Viability of Glioblastoma and Neural Progenitor Cells in Culture
Abstract Evidence suggests that the nonpsychotropic cannabis-derived compound, cannabidiol (CBD), has antineoplastic activity in multiple types of cancers,…
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Id-1 is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
Abstract Glioblastoma (GBM) is the most common form of primary adult brain tumors. A majority of GBMs grow…