Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
Abstract The aggressive behavior of Glioblastoma multiforme (GBM) is mainly due to high invasiveness and proliferation rate as…
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Dr. David Allen Explains Medical Cannabis
Dr. David Allen discusses how the rules of engagement in the war on drugs are being violated by…
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Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
Abstract Colon cancer affects millions of individuals in Western countries. Cannabidiol, a safe and non-psychotropic ingredient of Cannabis sativa,…
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Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1
Although cannabinoids exhibit a broad variety of anticarcinogenic effects, their potential use in cancer therapy is limited by their psychoactive…
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Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
Abstract The cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor agonist Δ9-tetrahydrocannabinol (THC) has been shown to be…
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Id-1: Regulator of EGFR and VEGF and potential target for colorectal cancer therapy
This study revealed that Id-1, EGFR and VEGF took part in development and progression of colorectal carcinomas and…
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Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers
Abstract [CONDENSED] …the 36-month survival rate of patients with high ID-1 was poor (60%), whereas that of the…
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Overexpression of Id-1 protein is a marker in colorectal cancer progression
Abstract The inhibitor of differentiation/DNA binding 1 (Id-1), a negative regulator of basic helix-loop-helix transcription factors, plays an…
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The non-psychoactive cannabidiol triggers caspase activation and oxidative stress in human glioma cells
Abstract Recently, we have shown that the non-psychoactive cannabinoid compound cannabidiol (CBD) induces apoptosis of glioma cells in vitro and…
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Level of Id-1 Protein Expression Correlates with Poor Differentiation, Enhanced Malignant Potential, and More Aggressive Clinical Behavior of Epithelial Ovarian Tumors
Abstract [condensed] Strong or moderate expression of Id-1 was a strong predictor for shorter overall survival. The level…
